The complement cascade evolved as a primitive surveillance system against pathogens 1. Some of the complement components have distinct antimicrobial activity. The fragments derived from C3 degradation ...

To assess the influence of circulating C3, we transplanted a group of C3 −/− recipients (n = 6) with normal kidneys in the reverse strain-combination. Here, survival was 13–24 days with a mean of 16.2 ...