Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

Paligenosis defines a tightly controlled program through which terminally differentiated cells re‑enter the cell cycle and ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, ...

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

A recent study has demonstrated the power of metabolic engineering in enhancing the antitumor activity of chimeric antigen receptor (CAR) macrophages (CAR-Ms) in solid tumors. By overexpressing the ...

Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

Potent antitumor activity of the KRASG12D inhibitor MRTX1133 in pancreatic cancer: Augmenting the nanoparticle-paclitaxel chemotherapy response. This is an ASCO Meeting Abstract from the 2025 ASCO ...

Diffuse large B-cell lymphoma (DLBCL) presenting with hyperlactatemia or lactic acidosis (LA) represents a rare, often fatal paraneoplastic ...