B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation ...

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

Introduction: in vivo partial cell reprogramming through transient overexpression of Oct3/4, Klf4, Sox2 and cMyc (OKSM) transcription factors generates de-differentiated or molecularly rejuvenated ...

Defining mechanisms of cardiomyocyte proliferation should guide the understanding of endogenous cardiac regeneration and could lead to novel treatments for diseases such as myocardial infarction. In ...

Various aspects related to carcinogenesis and cancer progression should comprehensively be investigated. It is believed that deep knowledge about malignant reprogramming can help to either prevent ...

Earlier this month, I posted an article about the negative effects of conditional love and have since received many requests for ways to heal and work through this. Many live with the effects of ...

School of Life Sciences, Tianjin University, Tianjin 300072, P. R. China Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin ...

The sequential production of cell types during neural development is controlled by temporal identity transcription factors, and heterochronic expression of these factors in progenitors reprograms ...

School of Public Health, Capital Medical University, Beijing 100069, P.R. China School of Public Health, Capital Medical University, Beijing 100069, P.R. China Key Laboratory of Environmental Medicine ...

Researchers from the Babraham Institute’s Epigenetics research programme have been able to learn more about naïve stem cell reprogramming following a genome wide functional screen. Their research, ...