Researchers at the University of Liverpool have identified distinctive biological characteristics within adenomyosis lesions ...

A new multiplex immunofluorescence workflow using standard laboratory equipment and open-source software enables detailed ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

Aging affects every organ in the body, yet we still know little about how the ovary changes over time. In a new study published in Nature Aging, Yale researchers created one of the most detailed maps ...

We developed a statistical method for Integrative and Reference-Informed Spatial Domain Detection for Spatial Transcriptomics. IRIS is a reference-informed integrative method for detecting spatial ...

The gut microbiome is not a mere spectator but an active player in colorectal cancer (CRC), driving tumor initiation and ...

Abstract: Clustering individual cells or spots based on their gene expression profiles in a spatial context is a powerful approach to uncovering the underlying biological diversity and relationships ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

The liver is a highly multifunctional organ that can perform many metabolic and immunological functions due to a highly complex spatially organised microarchitecture that is disturbed in many liver ...

Lymph nodes are key sites of adaptive immune responses, yet how immune cells coordinate their activities in space and time remains poorly understood. We combined high-resolution spatial ...

Spatial EcoTyper is a versatile framework for identifying spatially distinct multicellular communities, termed spatial ecotypes, from single-cell spatial transcriptomics data. In addition, it provides ...